RT journal article
T1 Biocatalytic Preparation of Chloroindanol Derivatives. Antifungal Activity and Detoxification by the Phytopathogenic Fungus Botrytis cinerea
A1 Pinedo Rivilla, Cristina
A1 Moraga Galindo, Javier
A1 Pérez Sasián, Guillermo
A1 Peña Hernández, Alba
A1 González Collado, Isidro
A1 Aleu Casatejada, Josefina
A2 Química Orgánica
K1 baker's yeast
K1 lipase
K1 biotransformation
K1 Botrytis cinerea
K1 chloroindanol derivatives
AB Indanols are a family of chemical compounds that have been widely studied due to their broad range of biological activity. They are also important intermediates used as synthetic precursors to other products with important applications in pharmacology. Enantiomerically pure chloroindanol derivatives exhibiting antifungal activity against the phytopathogenic fungus Botrytis cinerea were prepared using biocatalytic methods. As a result of the biotransformation of racemic 6-chloroindanol (1) and 5-chloroindanol (2) by the fungus B. cinerea, the compounds anti-(+)-6-chloroindan-1,2-diol (anti-(+)-7), anti-(+)-5-chloroindan-1,3-diol (anti-(+)-8), syn-(+)-5-chloroindan-1,3-diol (syn-(+)-8), syn-(-)-5-chloroindan-1,3-diol (syn-(-)-8), and anti-(+)-5-chloroindan-1,2-diol (anti-(+)-9) were isolated for the first time. These products were characterized by spectroscopic techniques and their enantiomeric excesses studied by chromatographic techniques. The results obtained in the biotransformation seem to suggest that the fungus B. cinerea uses oxidation reactions as a detoxification mechanism.
PB MDPI
SN 2223-7747
YR 2020
FD 2020-12
LK http://hdl.handle.net/10498/24362
UL http://hdl.handle.net/10498/24362
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 04-nov-2026