RT journal article T1 A Comprehensive Integrated Genetic Map of the Complete Karyotype of Solea senegalensis (Kaup 1858) A1 Merlo Torres, Manuel Alejandro A1 Portela Bens, Silvia A1 Rodríguez Jiménez, María Esther A1 García Angulo, Aglaya María A1 Cross Pacheco, Ismael A1 Arias Pérez, Alberto A1 García, Emilio A1 Rebordinos González, Laureana A2 BiomedicinaBiotecnología y Salud Pública K1 Solea senegalensis K1 cytogenetic map K1 BAC-FISH K1 physical map K1 comparative genomics AB Solea senegalensis aquaculture production has experienced a great increase in the last decade and, consequently, the genome knowledge of the species is gaining attention. In this sense, obtaining a high-density genome mapping of the species could offer clues to the aquaculture improvement in those aspects not resolved so far. In the present article, a review and new processed data have allowed to obtain a high-density BAC-based cytogenetic map of S. senegalensis beside the analysis of the sequences of such BAC clones to achieve integrative data. A total of 93 BAC clones were used to localize the chromosome complement of the species and 588 genes were annotated, thus almost reaching the 2.5% of the S. senegalensis genome sequences. As a result, important data about its genome organization and evolution were obtained, such as the lesser gene density of the large metacentric pair compared with the other metacentric chromosomes, which supports the theory of a sex proto-chromosome pair. In addition, chromosomes with a high number of linked genes that are conserved, even in distant species, were detected. This kind of result widens the knowledge of this species' chromosome dynamics and evolution. PB MDPI SN 2073-4425 YR 2021 FD 2021-01 LK http://hdl.handle.net/10498/24538 UL http://hdl.handle.net/10498/24538 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 11-nov-2026