RT journal article
T1 MicroRNAs overexpressed in Crohn's disease and their interactions with mechanisms of epigenetic regulation explain novel aspects of Crohn's disease pathogenesis
A1 Fernández Ponce, Cecilia Matilde
A1 Navarro Quiroz, Roberto
A1 Díaz Pérez, Anderson
A1 Aroca Martínez, Gustavo
A1 Cadena Bonfanti, Andrés
A1 Acosta Hoyos, Antonio
A1 Gómez Escorcia, Lorena
A1 Hernández Agudelo, Sandra
A1 Orozco Sánchez, Christian
A1 Villarreal Camacho, José
A1 Atencio Ibarra, Linda
A1 Consuegra Machado, José
A1 Espinoza Garavito, Alberto
A1 García Cózar, Francisco José
A1 Navarro Quiroz, Elkin
A2 BiomedicinaBiotecnología y Salud Pública
K1 MicroRNA
K1 Crohn&#8217
K1 s disease
K1 Epigenetic mechanisms
K1 Post-translational modifications
K1 T cells
AB Background In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease. Methods We used HMDD and Bibliometrix R-package in order to identify the miRNAs overexpressed in CD. The identified enzymes associated with epigenetic mechanisms and post-translational modifications, regulated by miRNAs upregulated in CD, were analyzed using String v11 database. Results We found 190 miRNAs with great abundance in patients with CD, of which 26 miRNAs regulate the gene expression of enzymes known to catalyze epigenetic modifications involved in essentials pathophysiological processes, such as chromatin architecture reorganization, immune response regulation including CD4+ T cells polarization, integrity of gut mucosa, gut microbiota composition and tumorigenesis. Conclusion The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.
PB BMC
SN 1868-7075
YR 2021
FD 2021
LK http://hdl.handle.net/10498/24644
UL http://hdl.handle.net/10498/24644
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026