RT journal article
T1 A Short-Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome
A1 Rosety Rodríguez, Manuel
A1 Bernardi, M.
A1 Elosegui, S.
A1 Rosety Rodríguez, Ignacio
A1 Díaz Ordóñez, Antonio Jesús
A1 Rosety Rodríguez, Miguel Ángel
A1 Brenes, F.
A1 Oliva-Pascual-Vaca, A.
A1 Alvero-Cruz, José Ramón
A1 Ordóñez Muñoz, Francisco Javier
A2 Anatomía y Embriología Humana
A2 Didáctica de la Educación FísicaPlástica y Musical
A2 Medicina
AB Previous studies have found aerobic training improved oxidative damage in people with Down syndrome (DS). However, there is a lack of information regarding the influence of resistance training on redox imbalance in this population. Accordingly, this study was conducted to determine the effect of resistance training (RT) on antioxidant defence system in sedentary adults with DS. Thirty-six male adults with DS were recruited through different community support groups. Eighteen were randomly assigned to perform a circuit RT program with 6 stations, 3 days/week for 12 weeks. Plasma total antioxidant status (TAS), reduced glutathione (GHS), ascorbate, serum alpha-tocopherol, and erythrocyte glutathione reductase activity were assessed. Plasma malondialdehyde (MDA) and carbonyl groups (CG) were assessed as markers of oxidative damage. Muscle strength was also measured. Dynamic torque of knee extensors and flexors as well as maximal handgrip strength was significantly improved after the completion of the training program. Plasma levels of TAS and erythrocyte glutathione reductase (GR) activity were significantly increased. Conversely, MDA and CG levels were significantly reduced. It was concluded RT improved antioxidant defence system and reduced oxidative damage in adults with DS. Further, long-term studies are required to determine whether the increased antioxidant system may improve clinical outcomes of adults with DS.
PB HINDAWI LTD
SN 1942-0900
YR 2021
FD 2021-01
LK http://hdl.handle.net/10498/24670
UL http://hdl.handle.net/10498/24670
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026