RT journal article
T1 Alzheimer's Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models
A1 Carranza Naval,  María José
A1 Vargas Soria, María
A1 Hierro Bujalance, Carmen
A1 Baena Nieto, María Gloria
A1 García Alloza, Mónica
A1 Infante-Garcia, Carmen
A1 Marco Delgado, Ángel José del
A2 BiomedicinaBiotecnología y Salud Pública
K1 Alzheimer's disease
K1 type 2 diabetes mellitus
K1 microbiota
K1 diet
K1 microglia
K1 inflammation
AB Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies show the association between AD and type 2 diabetes (T2DM), although the mechanisms are not fully understood. Dietary habits and lifestyle, that are risk factors in both diseases, strongly modulate gut microbiota composition. Also, the brain-gut axis plays a relevant role in AD, diabetes and inflammation, through products of bacterial metabolism, like short-chain fatty acids. We provide a comprehensive review of current literature on the relation between dysbiosis, altered inflammatory cytokines profile and microglia in preclinical models of AD, T2DM and models that reproduce both diseases as commonly observed in the clinic. Increased proinflammatory cytokines, such as IL-1 beta and TNF-alpha, are widely detected. Microbiome analysis shows alterations in Actinobacteria, Bacteroidetes or Firmicutes phyla, among others. Altered alpha- and beta-diversity is observed in mice depending on genotype, gender and age; therefore, alterations in bacteria taxa highly depend on the models and approaches. We also review the use of pre- and probiotic supplements, that by favoring a healthy microbiome ameliorate AD and T2DM pathologies. Whereas extensive studies have been carried out, further research would be necessary to fully understand the relation between diet, microbiome and inflammation in AD and T2DM.
PB MDPI
SN 2218-273X
YR 2021
FD 2021-02
LK http://hdl.handle.net/10498/24704
UL http://hdl.handle.net/10498/24704
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026