RT journal article
T1 Anti-Inflammatory (M2) Response Is Induced by a sp(2)-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy
A1 Cano-Cano, Fátima
A1 Alcalde-Estévez, Elena
A1 Gómez Jaramillo, María Laura
A1 Iturregui, Marta
A1 Sánchez-Fernández, Elena M.
A1 García-Fernández, José M.
A1 Ortiz Mellet, Carmen
A1 Campos Caro, Antonio
A1 López Tinoco, Cristina
A1 Aguilar Diosdado, Manuel
A1 Valverde, Ángela M.
A1 Arroba Espinosa, Ana Isabel
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
K1 sp(2)-iminosugar glycolipids
K1 diabetic retinopathy
K1 microglia
K1 immunomodulation
K1 M2 response
AB Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (S (S),1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp(2)-iminosugar glycolipid (sp(2)-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. Moreover, pretreatment with (Ss)-DS-ONJ increased Heme-oxygenase (HO)-1 as well as interleukin 10 (IL10) expression in LPS-stimulated microglial cells, thereby promoting M2 (anti-inflammatory) response by the induction of Arginase-1. The results strongly suggest that this is the likely molecular mechanism involved in the anti-inflammatory effects of (S (S))-DS-ONJ in microglia. (S (S))-DS-ONJ further reduced gliosis in retinal explants from type 1 diabetic BB rats, which is consistent with the enhanced M2 response. In conclusion, targeting microglia polarization dynamics in M2 status by compounds with anti-inflammatory activities offers promising therapeutic interventions at early stages of DR.
PB FRONTIERS MEDIA SA
SN 1664-3224
YR 2021
FD 2021-03
LK http://hdl.handle.net/10498/24795
UL http://hdl.handle.net/10498/24795
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026