RT doctoral thesis
T1 Osmoregulatory role of the intestine in fish physiology. Evolutionary, environmental, and toxicant implications
T2 Rol osmorregulador del intestino en la fisiología de peces. Implicaciones evolutivas, ambientales y tóxicas
A1 Barany Ruiz, Andre
A2 Biología
K1 Osmoregulation
K1 Intestine
K1 Water and ion absorption
K1 Solea senegalensis
K1 Petromyzon marinus
K1 Sparus aurata
K1 Aflatoxin B1
K1 Epithelial barrier
K1 Ussing chamber
K1 Electrophysiology
K1 Ionic transport proteins
AB The earliest fishes arose circa 500 million years ago (mya) during the Ordovician and persevered throughout several mass extinction events. Unknown fishes' lines became extinct in life history (e.g., conodonts, ostracoderms, acanthodians, placoderms, etc.). It is so that extant lineages may be speculated to have been successful due to several hypotheses: i) an internal milieu composition that provided a buffering medium, protecting them from acute and threatening changes (e.g., ion compositions, temperatures, pH, etc.) and supporting life and giving time for adaption; ii) an high evolving plasticity, thus, generating heritable phenotypes and diversifying species across a wide range of habitats (resilience); and/or iii) the influence of stochastic processes on genetics fate.Most of this Ph.D. Thesis aims to provide new insights into the ion regulatory mechanisms in different fishes' intestines to compare them. Specifically, we focus on crucial ion transporter proteins such as Na+/K+-ATPase (NKA), H+-ATPase (VHA), Na+:K+:2Clˉ cotransporter (NKCC), Na+:Clˉ (NCC). Moreover, we provide new insights on the molecular and physiological mechanisms in the most basal ion- and osmo- regulator, the sea lamprey (Petromyzon marinus), and in a much recent diverged teleost, the Senegalese sole (Solea Senegalensis). Additionally, aquafeeds' effects contaminated with aflatoxin B1 on growth performance and intestinal physiology are also examined, using gilthead seabream (Sparus aurata), a well-known farmed biological model.
YR 2021
FD 2021-04-27
LK http://hdl.handle.net/10498/24806
UL http://hdl.handle.net/10498/24806
LA eng
NO Ejemplar aprobado de Tesis Doctoral con calificación sobresaliente "Cum Laude" por la Universidad de Cádiz
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026