RT journal article
T1 Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
A1 Montes de Oca García, Adrian
A1 Pérez-Bey, Alejandro
A1 Velázquez Díaz, Daniel
A1 Corral Pérez, Juan
A1 Opazo Díaz, Edgardo
A1 Rebollo Ramos, María
A1 Gómez-Gallego, Félix
A1 Cuenca García, María Magdalena
A1 Casals Vázquez, Cristina
A1 Ponce González, Jesús Gustavo
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 genetic association studies
K1 heart diseases
K1 lipid metabolism
K1 healthy lifestyle
K1 angiotensin-converting enzyme
K1 obesity
AB There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 +/- 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 +/- 11.8 mmHg; ID: 116.7 +/- 6.3 mmHg; II: 109.4 +/- 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 +/- 10.8%; ID: 22.6 +/- 9.7%; II: 19.3 +/- 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 +/- 3.0 vs. 6.5 +/- 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 +/- 2.3 vs. 7.6 +/- 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO.
PB MDPI
SN 1660-4601
YR 2021
FD 2021-04
LK http://hdl.handle.net/10498/24879
UL http://hdl.handle.net/10498/24879
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026