RT journal article T1 Drastic Reductions in Mental Well-Being Observed Globally During the COVID-19 Pandemic: Results From the ASAP Survey A1 Wilke, Jan A1 Hollander, Karsten A1 Mohr, Lisa A1 Edouard, Pascal A1 Fossati, Chiara A1 González-Gross, Marcela A1 Sánchez Ramírez, Celso A1 Laiño, Fernando A1 Tan, Benedict A1 Pillay, Julian David A1 Pigozzi, Fabio A1 Jiménez Pavón, David A1 Sattler, Matteo C. A1 Jaunig, Johannes A1 Zhang, Mandy A1 van Poppel, Mireille A1 Heidt, Christoph A1 Willwacher, Steffen A1 Vogt, Lutz A1 Verhagen, Evert A1 Hespanhol, Luiz A1 Tenforde, Adam S. A2 Didáctica de la Educación FísicaPlástica y Musical K1 coronavirus K1 WHO-5 K1 SF-36 K1 psychological health K1 pain K1 lockdowns AB Most countries affected by the COVID-19 pandemic have repeatedly restricted public life to control the contagion. However, the health impact of confinement measures is hitherto unclear. We performed a multinational survey investigating changes in mental and physical well-being (MWB/PWB) during the first wave of the pandemic. A total of 14,975 individuals from 14 countries provided valid responses. Compared to pre-restrictions, MWB, as measured by the WHO-5 questionnaire, decreased considerably during restrictions (68.1 +/- 16.9 to 51.9 +/- 21.0 points). Whereas 14.2% of the participants met the cutoff for depression screening pre-restrictions, this share tripled to 45.2% during restrictions. Factors associated with clinically relevant decreases in MWB were female sex (odds ratio/OR = 1.20, 95% CI: 1.11-1.29), high physical activity levels pre-restrictions (OR = 1.29, 95% CI 1.16-1.42), decreased vigorous physical activity during restrictions (OR = 1.14, 95% CI: 1.05-1.23), and working (partially) outside the home vs. working remotely (OR = 1.29, 95% CI: 1.16-1.44/OR = 1.35, 95% CI: 1.23-1.47). Reductions, although smaller, were also seen for PWB. Scores in the SF-36 bodily pain subscale decreased from 85.8 +/- 18.7% pre-restrictions to 81.3 +/- 21.9% during restrictions. Clinically relevant decrements of PWB were associated with female sex (OR = 1.62, 95% CI: 1.50-1.75), high levels of public life restrictions (OR = 1.26, 95% CI: 1.18-1.36), and young age (OR = 1.10, 95% CI: 1.03-1.19). Study findings suggest lockdowns instituted during the COVID-19 pandemic may have had substantial adverse public health effects. The development of interventions mitigating losses in MWB and PWB is, thus, paramount when preparing for forthcoming waves of COVID-19 or future public life restrictions. PB FRONTIERS MEDIA SA SN 2296-858X YR 2021 FD 2021-03 LK http://hdl.handle.net/10498/24932 UL http://hdl.handle.net/10498/24932 LA eng NO DJ-P is supported by a grant from the Spanish Ministry of Science and Innovation-MINECO (RYC-2014-16938). The research fellowship of KH was funded by the German Research Foundation (Grant no. HO 6214/2-1). DS Repositorio Institucional de la Universidad de Cádiz RD 21-sep-2026