RT journal article
T1 Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
A1 Cruz Melguizo, Sara
A1 de la Cruz Conty, María Luisa
A1 Carmona Payán, Paola
A1 Abascal-Saiz, Alejandra
A1 Pintando Recarte, Pilar
A1 González Rodríguez, Laura
A1 Cuenca Marín, Celia
A1 Martínez Varea, Alicia
A1 Oreja Cuesta, Ana Belén
A1 Prats Rodríguez, Pilar
A1 Fernández Buhigas, Irene
A1 Rodríguez Gallego, María Victoria
A1 Fernández Alonso, Ana María
A1 López Pérez, Rocío
A1 Broullon Molanes, José Román
A1 Encinas Pardilla, María Begoña
A1 Ramírez Gómez, Mercedes
A1 Gimeno Gimeno, María Joaquina
A1 Sánchez Muñoz, Antonio
A1 Martínez-Pérez, Oscar
A1 Spanish Obstetric Emergency Group (S.O.E.G.)
A2 Materno-Infantil y Radiología
K1 SARS-CoV-2
K1 coronavirus
K1 COVID-19
K1 pregnancy
K1 delivery
K1 perinatal outcomes
K1 premature birth
K1 maternal complications
AB Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms).
PB MDPI
SN 1999-4915
YR 2021
FD 2021-05
LK http://hdl.handle.net/10498/25139
UL http://hdl.handle.net/10498/25139
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026