RT journal article
T1 Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment
A1 Valor López, Diego
A1 Montes Herrera, Antonio
A1 Monteiro, Marilia
A1 García Casas, Ignacio
A1 Pereyra López, Clara María
A1 Martínez de la Ossa Fernández, Enrique José
A2 Ingeniería Química y Tecnología de Alimentos
K1 PLGA
K1 supercritical CO2 foaming
K1 rutin
K1 scaffolds
K1 release profile
AB Poly(D,L,-lactide-co-glycolide) (PLGA) foam samples impregnated with rutin were successfullyproduced by supercritical foaming processes. A number of parameters such as pressure(80–200 bar), temperature (35–55  C), depressurization rate (5–100 bar/min), ratio lactide:glycolide ofthe poly(D,L,-lactide-co-glycolide) (50:50 and 75:25) were studied to determine their effect on the expansionfactor and on the glass transition temperature of the polymer foams and their consequenceson the release profile of the rutin entrapped in them. The impregnated foams were characterized byscanning electron microscopy, differential scanning calorimetry, and mercury intrusion porosimetry.A greater impregnation of rutin into the polymer foam pores was observed as pressure was increased.The release of rutin in a phosphate buffer solution was investigated. The controlled release testsconfirmed that the modification of certain variables would result in considerable differences in thedrug release profiles. Thus, five-day drug release periods were achieved under high pressure andtemperature while the depressurization rate remained low.
PB MDPI
SN 2073-4360
YR 2021
FD 2021-05
LK http://hdl.handle.net/10498/25203
UL http://hdl.handle.net/10498/25203
LA eng
NO This research was funded by Spanish Ministry of Economy, Industry and Competitiveness: CTQ2017-86661-R.
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026