RT journal article
T1 Pharmacological Activities of Aminophenoxazinones
A1 García Zorrilla, Jesús
A1 Rial Cumbrera, Carlos
A1 Cabrera Torrejón, Daniel
A1 González Molinillo, José María
A1 Varela Montoya, Rosa María
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 aminophenoxazinone
K1 drug
K1 Phx-3
K1 cytotoxicity
K1 cancer
K1 antibacterial
K1 antifungal
K1 virus
K1 in vitro
K1 in vivo
AB Aminophenoxazinones are degradation products resulting from the metabolism of different plant species, which comprise a family of natural products well known for their pharmacological activities. This review provides an overview of the pharmacological properties and applications proved by these compounds and their structural derivatives during 2000-2021. The bibliography was selected according to our purpose from the references obtained in a SciFinder database search for the Phx-3 structure (the base molecule of the aminophenoxazinones). Compounds Phx-1 and Phx-3 are among the most studied, especially as anticancer drugs for the treatment of gastric and colon cancer, glioblastoma and melanoma, among others types of relevant cancers. The main information available in the literature about their mechanisms is also described. Similarly, antibacterial, antifungal, antiviral and antiparasitic activities are presented, including species related directly or indirectly to significant diseases. Therefore, we present diverse compounds based on aminophenoxazinones with high potential as drugs, considering their levels of activity and few adverse effects.
PB MDPI
SN 1420-3049
YR 2021
FD 2021-06
LK http://hdl.handle.net/10498/25290
UL http://hdl.handle.net/10498/25290
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026