RT journal article
T1 The Role of Glycosyltransferases in Colorectal Cancer
A1 Fernández Ponce, Cecilia Matilde
A1 Geribaldi Doldán, Noelia
A1 Sánchez Gomar, Ismael
A1 Navarro Quiroz, Roberto
A1 Atencio Ibarra, Linda
A1 Gómez Escorcia, Lorena
A1 Fernández-Cisnal, R.
A1 Aroca Martínez, Gustavo
A1 García Cózar, Francisco José
A1 Navarro Quiroz, Elkin
A2 Anatomía y Embriología Humana
A2 BiomedicinaBiotecnología y Salud Pública
K1 colorectal cancer (CRC)
K1 glycosyltransferase
K1 glycosylation
K1 post-translational modification
AB Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Posttranslationalmodifications (PTMs) have been extensively studied in malignancies due to its relevancein tumor pathogenesis and therapy. This review is focused on the dysregulation of glycosyltransferaseexpression in CRC and its impact in cell function and in several biological pathways associatedwith CRC pathogenesis, prognosis and therapeutic approaches. Glycan structures act as interfacemolecules between cells and their environment and in several cases facilitate molecule function.CRC tissue shows alterations in glycan structures decorating molecules, such as annexin-1, mucins,heat shock protein 90 (Hsp90),  1 integrin, carcinoembryonic antigen (CEA), epidermal growthfactor receptor (EGFR), insulin-like growth factor-binding protein 3 (IGFBP3), transforming growthfactor beta (TGF- ) receptors, Fas (CD95), PD-L1, decorin, sorbin and SH3 domain-containingprotein 1 (SORBS1), CD147 and glycosphingolipids. All of these are described as key moleculesin oncogenesis and metastasis. Therefore, glycosylation in CRC can affect cell migration, cell–celladhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemnessregulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization andgut microbiota composition; all such functions are associated with the prognosis and evolution of thedisease. According to these findings, multiple strategies have been evaluated to alter oligosaccharideprocessing and to modify glycoconjugate structures in order to control CRC progression and preventmetastasis. Additionally, immunotherapy approaches have contemplated the use of neo-antigens,generated by altered glycosylation, as targets for tumor-specific T cells or engineered CAR (Chimericantigen receptors) T cells.
PB MDPI
SN 1422-0067
YR 2021
FD 2021-06
LK http://hdl.handle.net/10498/25300
UL http://hdl.handle.net/10498/25300
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026