RT journal article T1 Prospective Associations of Physical Activity and Health-Related Physical Fitness in Adolescents with Down Syndrome: The UP&DOWN Longitudinal Study A1 Suarez-Villadat, Borja A1 Villagra, Ariel A1 Veiga, Oscar L. A1 Cabanas Sanchez, Veronica A1 Izquierdo Gómez, Rocío A1 UP&DOWN Study Group A2 Didáctica de la Educación FísicaPlástica y Musical K1 physical fitness K1 longitudinal study K1 accelerometer-based PA K1 Down syndrome AB (1) Background: Numerous studies have focused on examining the association between PA levels and health-related physical fitness components in children or adolescents without disabilities. However, research on the association between PA and health-related physical fitness in adolescents with DS (Down syndrome) is limited, and most of the previous studies have been developed with a cross-sectional perspective. Therefore, the aim of the present study was to assess the prospective association of accelerometer-based PA at baseline with health-related physical fitness at a 2-year follow-up in a relatively large sample of adolescents with DS from the UP&DOWN study. (2) Methods: A total of 92 adolescents with DS (58 males) between 11 and 20 years old with full data were eligible from an initial sample of 110 participants. Fitness was assessed by the ALPHA health-related fitness test battery for youth, and physical activity was assessed by Actigraph accelerometers. (3) Results: The high tertile of total PA was related to decreased motor (Beta [95% CI] = -1.46 [-2.88; -0.05]) and cardiorespiratory fitness (Beta [95% CI] = -2.22 [-4.42; 0.02]) in adolescents with DS. (4) Conclusions: In adolescents with DS, (i) PA level was not prospectively associated with muscular fitness and (ii) high levels of total PA at the baseline were inversely associated with motor and cardiorespiratory fitness at the 2-year follow-up. For comparative purposes, these relationships were also examined in a subsample of adolescents without DS. PB MDPI SN 1660-4601 YR 2021 FD 2021-06 LK http://hdl.handle.net/10498/25302 UL http://hdl.handle.net/10498/25302 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 12-nov-2026