RT journal article
T1 Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis
A1 Barca-Hernando, María
A1 Muñoz-Martin, Andres J.
A1 Rios-Herranz, Eduardo
A1 Garcia-Escobar, Ignacio
A1 Beato, Carmen
A1 Font, Carme
A1 Oncala-Sibajas, Estefanía
A1 Revuelta-Rodriguez, Alfonso
A1 Areses, Maria Carmen
A1 Rivas-Jimenez, Victor
A1 Ballaz-Quincoces, Aitor
A1 Moreno-Santos, Maria Angeles
A1 López Sáez, José Juan Bosco
A1 Gallego-Gallego, Iria
A1 Elias-Hernandez, Teresa
A1 Asensio-Cruz, Maria Isabel
A1 Chasco-Eguilaz, Leyre
A1 Garcia-Gonzalez, Gonzalo
A1 Estevez-Garcia, Purificación
A1 Marin-Barrera, Lucía
A1 Otero-Candelera, Remedios
A1 Lopez-Ruz, Sergio
A1 Lima-Alvarez, Jorge
A1 Sanchez-Diaz, José María
A1 Real-Dominguez, Macarena
A1 Borrego-Delgado, Maria Carmen
A1 Marin-Romero, Samira
A1 Jara-Palomares, Luis
A2 Medicina
K1 anaemia
K1 neoplasm
K1 quality of life
AB The impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients.Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically.
PB MDPI
SN 2072-6694
YR 2021
FD 2021-06
LK http://hdl.handle.net/10498/25316
UL http://hdl.handle.net/10498/25316
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026