RT journal article T1 A Study on the Phytotoxic Potential of the Seasoning Herb Marjoram (Origanum majorana L.) Leaves A1 Cala Peralta, Antonio A1 Salcedo, José R. A1 Torres Martínez, Ascensión A1 Varela Montoya, Rosa María A1 González Molinillo, José María A1 Macías Domínguez, Francisco Antonio A2 Química Orgánica K1 marjoram K1 Origanum majorana L. K1 bioguided fractionation K1 wheat coleoptile K1 bioassay K1 spice K1 phytotoxic K1 flavonoid K1 monoterpene K1 diterpene AB In the search of new alternatives for weed control, spices appear as an option with great potential. They are rich in bioactive natural products and edible, which might minimize toxicity hazard. Marjoram (Origanum majorana L.) is an aromatic herb that has been widely employed as a seasoning herb in Mediterranean countries. Although marjoram boasts a plethora of therapeutic properties (painkiller, antibiotic, treatment for intestinal disorders, etc.), the potential for its extracts for weed control is still to be more thoroughly explored. In order to determine their phytotoxic potential, marjoram leaves were subjected to different bioguided extraction processes, using water, ethyl acetate, acetone or methanol. The most active extract (acetone) was sequentially fractionated to identify its most active compounds. This fractionation led to the isolation and identification of 25 compounds that were classified as monoterpenes, diterpenes or flavonoids. Among them, a new compound named majoradiol and several compounds are described in marjoram for the first time. The phytotoxicity of the major compounds to etiolated wheat coleoptiles was compared against that of the commercial herbicide (Logran(R)), with similar or higher activity in some cases. These results confirm the extraordinary potential of the extracts from this edible plant to develop safer and more environmentally friendly herbicides. PB MDPI SN 1420-3049 YR 2021 FD 2021-06 LK http://hdl.handle.net/10498/25323 UL http://hdl.handle.net/10498/25323 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 06-nov-2026