RT journal article
T1 Supercritical Impregnation of Ketoprofen into Polylactic Acid for Biomedical Application: Analysis and Modeling of the Release Kinetic
A1 Verano Naranjo, Lidia
A1 Cejudo Bastante, Cristina
A1 Casas Cardoso, Lourdes
A1 Mantell Serrano, Casimiro
A1 Martínez de la Ossa Fernández, Enrique José
A2 Ingeniería Química y Tecnología de Alimentos
K1 supercritical solvent impregnation
K1 drug release
K1 polylactic acid
K1 ketoprofen
K1 swelling
K1 drug loading
K1 drug delivery implants
AB Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic and antipyretic effects. If it is administered in a controlled form by means of different dosing devices, it acts throughout the patient's recovery period improving its efficacy. This study intends to support the use of supercritical solvent impregnation (SSI) as an efficient technique to develop polylactic acid (PLA) functionalized with ketoprofen, for use as controlled drug release devices. For this purpose, firstly, the influence of different SSI variables on the desirable swelling of the polymer structure, while avoiding their foaming, were evaluated. Then, the resulting ketoprofen loading was evaluated under different pressure/temperature conditions. It was generally found that as pressure and temperature are higher, the drug impregnation loads also increase. The maximum impregnation loads (at about 9% KET/PLA) were obtained at 200 bar and 75 degrees C. In vitro drug release tests of the impregnated compound were also carried out, and it was found that drug release profiles were also dependent on the specific pressure and temperature conditions used for the impregnation of each polymer filament.
PB MDPI
SN 2073-4360
YR 2021
FD 2021-06
LK http://hdl.handle.net/10498/25399
UL http://hdl.handle.net/10498/25399
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026