RT journal article
T1 Predictive Factors of Pulmonary Embolism in Older Patients with SARS-CoV-2: The OCTA-COVID-19 Study
A1 Quezada‑Feijoo, Maribel
A1 Ramos, Mónica
A1 Lozano-Montoya, Isabel
A1 Toro Cebada, Rocío
A1 Jaramillo-Hídalgo, Javier
A1 Fernández de la Puente, Eva
A1 Garmendia, Blanca
A1 Carrillo, Pamela
A1 Cristofori, Giovanna
A1 Goñi Rosón, Saleta
A1 Ayala, Rocío
A1 Sarro, Mónica
A1 Gómez-Pavón, Francisco J.
A2 Medicina
K1 pulmonary embolism
K1 older
K1 COVID-19
AB Background: The risk of pulmonary embolism (PE) has not been studied in older patients affected by COVID-19. We aimed to assess PE incidence and risk factors in a population of older patients infected with SARS-CoV-2. Methods: An ambispective, observational cohort study. A total of 305 patients >= 75 years old had the SARS-CoV-2 infection from March to May 2020. The incidence rate of PE was estimated as the proportion of new cases within the whole sample. Youden's index was used to assess the cutoff point of D-dimer. To select factors associated with the risk of PE, time-to-event analyses were performed using cause-specific hazard models. Results: In total, 305 patients with a median age of 87 years (62.3% female) were studied; 67.9% were referred from nursing homes and 90.4% received any type of anticoagulation. A total of 64.9% showed frailty and 44% presented with dementia. The PE incidence was 5.6%. The cutoff value of a D-dimer level over 2.59 mg/L showed a sensitivity of 82.4% and specificity of 73.8% in discriminating a PE diagnosis. In the multivariate analysis, the factors associated with PE were previous oncological events and D-dimer levels. Conclusions: The PE incidence was 5.6%, and major risk factors for PE were oncological antecedents and increased plasma D-dimer levels.
PB MDPI
SN 2077-0383
YR 2021
FD 2021-07
LK http://hdl.handle.net/10498/25564
UL http://hdl.handle.net/10498/25564
LA eng
NO This work was partially supported by grants (to M.Q.-F., J.G.-P.) from the "New announcement for extraordinary initiative fund UAX-Santander COVID-19," Alfonso X el Sabio University.
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026