RT journal article T1 Bioactive Diterpenes from the Brazilian Native Plant (Moquiniastrum pulchrum) and Their Application in Weed Control A1 Vela Benavides, Fátima A1 Anese, Simoni A1 Varela Montoya, Rosa María A1 Torres Martínez, Ascensión A1 González Molinillo, José María A1 Macías Domínguez, Francisco Antonio A2 Química Orgánica K1 Moquiniastrum pulchrum K1 flavones K1 diterpenes K1 phytotoxic K1 coleoptiles K1 weeds AB Even today, weeds continue to be a considerable problem for agriculture. The application of synthetic herbicides produces serious environmental consequences, and crops suffer loss of their activity due to the appearance of new resistant weed biotypes. Our aim is to develop new effective natural herbicides that improve the problem of resistance and do not harm the environment. This work is focused on a bioassay-guided isolation and the characterization of natural products present in Moquiniastrum pulchrum leaves with phytotoxic activity and its preliminary application in weeds. Moquiniastrum pulchrum was selected for two reasons: it is an abundant species in the Cerrado region (the second most important ecosystem in Brazil, after the Amazon)-the explanation behind its being a dominant species is a major focus of interest-and it has traditional employment in folk medicine. Six major compounds were isolated in this plant: one flavone and five diterpenes, two of which are described for the first time in the literature. Four of the six compounds exhibited phytotoxic activity in the bioassays performed. The results confirmed the phytotoxic potential of this plant, which had not been investigated until now. PB MDPI SN 1420-3049 YR 2021 FD 2021-08 LK http://hdl.handle.net/10498/25680 UL http://hdl.handle.net/10498/25680 LA eng NO This research was supported by CAPES-Coordination for the Improvement of Higher Education Personnel (Brazil) (Project 88881.119937/2016-01) and 'Ministerio de Economia, Industria y Competitividad' (MINEICO), Spain, Project AGL2017-88-083-R. DS Repositorio Institucional de la Universidad de Cádiz RD 12-nov-2026