RT journal article T1 Muscle Damage Biomarkers in Congestion Weeks in English Premier League Soccer Players: A Prospective Study for Two Consecutive Seasons A1 García-Romero-Pérez, Álvaro A1 Ordóñez Muñoz, Francisco Javier A1 Reyes-Gil, Fernando A1 Rodríguez-López, Elena Sonsoles A1 Oliva-Pascual-Vaca, Ángel A2 Anatomía y Embriología Humana K1 soccer K1 creatine kinase K1 muscle damage K1 fatigue K1 GPS K1 high speed running AB The current study was conducted to compare muscle damage biomarkers in single- vs. multi-match weeks in elite soccer players for two consecutive seasons. A secondary objective was to analyze the influence of playing position and exposure time on muscle damage in single- vs. multi-match weeks. This is a prospective cohort study performed in a professional elite soccer club in the English Premier League during the 2018-2019 and 2019-2020 seasons up until the lockdown due to the COVID-19 pandemic. Data were collected in the Medical Department Room of an English Premier League Club before and after the soccer game from a total of 29 elite soccer players (mean +/- S.D.; age = 27.59 +/- 3.83 years; height = 1.83 +/- 0.05 m; body mass = 80.16 +/- 7.45 kg) who were enrolled in the club during both seasons. The main outcome measurements were creatine kinase (CK), weight, lean mass, % fat DEXA, high speed running, total distance, density of total distance and high-speed running and wellbeing questionnaires. Significance was set at p < 0.05. Players who completed more than 60 min in the previous game had significantly increased pregame CK levels and fatigue in multi-match weeks. Midfielders had both significantly increased pregame CK and muscle soreness in multi-match weeks. Midfielders and players with an exposure time of at least 60 min showed higher pregame CK values that should play a key role for deciding substitutions. PB MDPI SN 1660-4601 YR 2021 FD 2021-08 LK http://hdl.handle.net/10498/25694 UL http://hdl.handle.net/10498/25694 LA eng NO We thank all the Medical Department at Watford FC, specially Chris Mogekwu and all the Physiotherapy Department at Camilo Jose Cela University. Both helped us get the sample and with the kindly support for this research. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation, and statement that results of the present study do not constitute endorsement by IJERPH.Document DS Repositorio Institucional de la Universidad de Cádiz RD 12-nov-2026