RT journal article
T1 Plasma microrna expression profile for reduced ejection fraction in dilated cardiomyopathy
A1 Calderón Domínguez, María
A1 Belmonte, Thalia
A1 Quezada‑Feijoo, Maribel
A1 Ramos, Mónica
A1 Calderón-Domínguez, Juan
A1 Campuzano, Oscar
A1 Mangas Rojas, Alipio
A1 Toro Cebada, Rocío
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
AB The left ventricular (LV) ejection fraction (EF) is key to prognosis in dilated cardiomyopathy (DCM).Circulating microRNAs have emerged as reliable biomarkers for heart diseases, included DCM.Clinicians need improved tools for greater clarification of DCM EF categorization, to identify highriskpatients. Thus, we investigated whether microRNA profiles can categorize DCM patients basedon their EF. 179-differentially expressed circulating microRNAs were screened in two groups: (1)non-idiopathic DCM; (2) idiopathic DCM. Then, 26 microRNAs were identified and validated in theplasma of ischemic-DCM (n = 60), idiopathic-DCM (n = 55) and healthy individuals (n = 44). We identifiedfourteen microRNAs associated with echocardiographic variables that differentiated idiopathic DCMaccording to the EF degree. A predictive model of a three-microRNA (miR-130b-3p, miR-150-5p andmiR-210-3p) combined with clinical variables (left bundle branch block, left ventricle end-systolicdimension, lower systolic blood pressure and smoking habit) was obtained for idiopathic DCM with aseverely reduced-EF. The receiver operating characteristic curve analysis supported the discriminativepotential of the diagnosis. Bioinformatics analysis revealed that miR-150-5p and miR-210-3p targetgenes might interact with each other with a high connectivity degree. In conclusion, our resultsrevealed a three-microRNA signature combined with clinical variables that highly discriminateidiopathic DCM categorization. This is a potential novel prognostic biomarker with high clinical value.
PB NATURE RESEARCH
SN 2045-2322
YR 2021
FD 2021-04
LK http://hdl.handle.net/10498/25716
UL http://hdl.handle.net/10498/25716
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026