RT journal article
T1 Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
A1 Benavente Fernández, Isabel
A1 Ruiz González, Estefanía
A1 Lubián Gutiérrez, Manuel
A1 Lubián Fernández, Simón Pedro
A1 Cabrales Fontela, Yunior
A1 Roca Cornejo, Cristina
A1 Olmo-Duran, Pedro
A1 Lubián López, Simón Pedro
A2 Materno-Infantil y Radiología
K1 3D ultrasonography
K1 preterm infant
K1 lineal measure
K1 brain volume
K1 magnetic resonance imaging
AB Objectives: The aim of this study is to explore if manually segmented total brain volume (TBV) from 3D ultrasonography (US) is comparable to TBV estimated by magnetic resonance imaging (MRI). We then wanted to test 2D based TBV estimation obtained through three linear axes which would enable monitoring brain growth in the preterm infant during admission.Methods: We included very low birth weight preterm infants admitted to our neonatal intensive care unit (NICU) with normal neuroimaging findings. We measured biparietal diameter, anteroposterior axis, vertical axis from US and MRI and TBV from both MRI and 3D US. We calculated intra- and interobserver agreement within and between techniques using the intraclass correlation coefficient and Bland-Altman methodology. We then developed a multilevel prediction model of TBV based on linear measurements from both US and MRI, compared them and explored how they changed with increasing age. The multilevel prediction model for TBV from linear measures was tested for internal and external validity and we developed a reference table for ease of prediction of TBV.Results: We used measurements obtained from 426 US and 93 MRI scans from 118 patients. We found good intra- and interobserver agreement for all the measurements. US measurements were reliable when compared to MRI, including TBV which achieved excellent agreement with that of MRI [ICC of 0.98 (95% CI 0.96-0.99)]. TBV estimated through 2D measurements of biparietal diameter, anteroposterior axis, and vertical axis was comparable among both techniques. We estimated the population 95% confidence interval for the mean values of biparietal diameter, anteroposterior axis, vertical axis, and total brain volume by post-menstrual age. A TBV prediction table based on the three axes is proposed to enable easy implementation of TBV estimation in routine 2D US during admission in the NICU.Conclusions: US measurements of biparietal diameter, vertical axis, and anteroposterior axis are reliable. TBV segmented through 3D US is comparable to MRI estimated TBV. 2D US accurate estimation of TBV is possible through biparietal diameter, vertical, and anteroposterior axes.
PB FRONTIERS MEDIA SA
SN 2296-2360
YR 2021
FD 2021-07
LK http://hdl.handle.net/10498/25746
UL http://hdl.handle.net/10498/25746
LA eng
NO This work was supported by the 2017 (PI0052/2017) and 2019 (ITI-0019-2019) ITI-Cadiz integrated territorial initiative for biomedical research European Regional Development Fund (ERDF) 2014-2020. Andalusian Ministry of Health and Families, Spain.
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026