RT journal article
T1 Trajectories of alcohol consumption during life and the risk of developing breast cancer
A1 Donat-Vargas, Carolina
A1 Guerrero-Zotano, Ángel
A1 Casas, Ana
A1 Baena Cañada, José Manuel
A1 Lope, Virginia
A1 Antolín, Silvia
A1 García-Sáenz, José Ángel
A1 Bermejo, Begoña
A1 Muñoz, Montserrat
A1 Ramos, Manuel
A1 de Juan, Ana
A1 Jara Sánchez, Carlos
A1 Sánchez-Rovira, Pedro
A1 Antón, Antonio
A1 Brunet, Joan
A1 Gavilá, Joaquín
A1 Salvador, Javier
A1 Arriola Arellano, Esperanza
A1 Bezares, Susana
A1 Fernández de Larrea-Baz, Nerea
A1 Pérez-Gómez, Beatriz
A1 Martín, Miguel
A1 Pollán, Marina
A2 Medicina
AB Background Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). Methods 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Results Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (>= 15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, >= 15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.
PB SPRINGERNATURE
SN 0007-0920
YR 2021
FD 2021-09
LK http://hdl.handle.net/10498/25827
UL http://hdl.handle.net/10498/25827
LA eng
NO This study was funded by the Fundacion Cientifica Asociacion Espanola Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2006 & 2016) (Marina Pollan), Sociedad Espanola de Oncologia Medica (SEOM) (Spanish Society of Medical Oncology) (Miguel Martin), Scholarship 'Contrato de atraccion de talento' from Community of Madrid (Carolina Donat-Vargas), Fundacion Cerveza y Salud 2005 (Beer and Health Foundation 2005) (Miguel Martin) and Federacion de Asociaciones de Mujeres con Cancer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer) (Miguel Martin, Marina Pollan).
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026