RT journal article T1 Search of New Tools for Weed Control Using Piptocarpha rotundifolia, a Dominant Species in the Cerrado A1 Anese, Simoni A1 Rial Cumbrera, Carlos A1 Varela Montoya, Rosa María A1 Torres Martínez, Ascensión A1 González Molinillo, José María A1 Macías Domínguez, Francisco Antonio A2 Química Orgánica K1 allelochemicals K1 piptocarphin A K1 isolation K1 phytotoxicity K1 weed control AB Piptocarpha rotundifolia (Less.) Baker stands out as one of the species with the highest frequency, density, and relative dominance in the Cerrado formations. However, no phytochemical studies have been carried out with this species to date. The aim of this study was to evaluate the phytotoxic activity of P. rotundifolia leaves in the search of new environmentally friendly tools for weed control. Thus, a wheat coleoptile and phytotoxic bioassay, using relevant agricultural weeds, was used to identify the most active extracts and fractions. The subsequent purification process allowed the isolation of 11 compounds, the phytotoxicity of which was evaluated in terms of wheat coleoptile elongation and with the most sensitive weeds. Piptocarphin A was found to be the major compound and the most active. To confirm its phytotoxic potential, the effect on Ipomea grandifolia grown in a hydroponic culture and on metaxylem cells was studied. The results obtained in this study demonstrate that the inhibitory activity displayed by P. rotundifolia leaf extract is mainly due to the presence of piptocarphin A. The phytotoxicity shown by P. rotundifolia leaf extract, and the isolated compounds, on weeds could provide new tools for weed control in agricultural fields. PB AMER CHEMICAL SOC SN 0021-8561 YR 2021 FD 2021-08 LK http://hdl.handle.net/10498/25876 UL http://hdl.handle.net/10498/25876 LA eng NO This research was supported by CAPES - Coordination for the Improvement of Higher Education Personnel (Brazil) (Project 88881.119937/2016-01) and "Ministerio de Economia, Industria y Competitividad" (MINEICO), Spain, Project AGL201788-083-R. DS Repositorio Institucional de la Universidad de Cádiz RD 08-nov-2026