RT journal article
T1 Synthesis of Pertyolides A, B, and C: A Synthetic Procedure to C-17-Sesquiterpenoids and a Study of Their Phytotoxic Activity
A1 Cárdenas, David M.
A1 Rial Cumbrera, Carlos
A1 Varela Montoya, Rosa María
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
AB C-17-sesquiterpenoids are a group of natural products that have been recently discovered. These compounds have the peculiarity of lacking the alpha,beta-methylene butyrolactone system, which is known to be quite relevant for many of the biological activities reported for sesquiterpene lactones. Unfortunately, the biological interest of C-17-sesquiterpenoids has not been studied in-depth, mainly due to the poor isolation yields in which they can be obtained from natural sources. Therefore, in order to allow a deeper study of these novel molecules, we have worked out a synthetic pathway that provides C-17-sesquiterpenoids in enough quantities from easily accessible sesquiterpene lactones to enable a more thorough investigation of their bioactivities. With this synthesis method, we have successfully synthesized, for the first time, three natural C-17-sesquiterpenoids, pertyolides A, B, and C, with good overall yields. Furthermore, we have also evaluated their phytotoxicity against etiolated wheat coleoptiles and corroborated that pertyolides B and C present strong phytotoxic activity.
PB AMER CHEMICAL SOC
SN 0163-3864
YR 2021
FD 2021-08
LK http://hdl.handle.net/10498/25878
UL http://hdl.handle.net/10498/25878
LA eng
NO This research was supported by the Ministerio de Economia, Industria y Competitividad (MINEICO), Spain, AGL2017-88083-R.
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026