RT journal article
T1 Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina
A1 Albendín García, María Gemma
A1 Aranda Quirós, Vanessa
A1 Coello Oviedo, María Dolores
A1 González Gómez, Carmen
A1 Rodríguez Barroso, María del Rocío
A1 Quiroga Alonso, José María
A1 Arellano López, Juana María
A2 Anatomía PatológicaBiología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología
A2 Tecnologías del Medio Ambiente
K1 microplastics
K1 simvastatin
K1 carbamazepine
K1 chlorpyrifos
K1 triclosan
K1 cholinesterase activity
AB Pharmaceutical products, as well as insecticides and antimicrobials, have been extensivelystudied, but knowledge of their effects—especially those caused by their mixtures with microplastics—on aquatic organisms remains limited. However, it should be borne in mind that the state ofknowledge on acute and chronic effects in aquatic organisms for pharmaceuticals and pesticides isnot similar. In response, this investigation analyzed the presence of microplastics (polyvinyl chloride)and their impacts on the toxicity of chlorpyrifos (an insecticide) and triclosan (an antibacterial) whenthey coincide in the environment, alongside the two most consumed drugs of their type (hypolipemicand anticonvulsant, respectively), namely simvastatin and carbamazepine, in Artemia salina. LC50 andcholinesterase enzyme activity were calculated to determine the possible neurotoxicity associatedwith emergent contaminants in the treatments. The LC50 values obtained were 0.006 mg/dm3for chlorpyrifos, 0.012 mg/dm3 for chlorpyrifos associated with microplastics, 4.979 mg/dm3 fortriclosan, 4.957 mg/dm3 for triclosan associated with microplastics, 9.35 mg/dm3 for simvastatin,10.29 mg/dm3 for simvastatin associated with microplastics, 43.25 mg/dm3 for carbamazepine and46.50 mg/dm3 for carbamazepine associated with microplastics in acute exposure. These resultsindicate that the presence of microplastics in the medium reduces toxicity, considering the LC50 values.However, exposure to chlorpyrifos and carbamazepine, both alone and associated with microplastics,showed a decline in cholinesterase activity, confirming their neurotoxic effect. Nevertheless, nosignificant differences were observed with the biomarker cholinesterase between the toxicant and thetoxicant with microplastics.
PB MDPI
SN 1660-4601
YR 2021
FD 2021-10
LK http://hdl.handle.net/10498/25943
UL http://hdl.handle.net/10498/25943
LA eng
NO This research was funded by the Ministerio de Ciencia, Investigacion y Universidades (REF.: RTI2018-096771-B-100).
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026