RT journal article
T1 Dosimetric impact of bladder filling on organs at risk with barium contrast in the small bowel for adjuvant vaginal cuff brachytherapy
A1 Salas Buzón, María del Carmen
A1 Gutiérrez Bayard, Lucía
A1 Rodríguez Sanchez, Raquel
A1 Quiñones Rodríguez, Luis Ángel
A1 Sayago Gil, Sarah
A1 Muñoz Higueras, Cristina
A2 Materno-Infantil y Radiología
K1 endometrial cancer
K1 vaginal cuff brachytherapy
K1 small bowel
K1 bladder distention
K1 barium
AB Purpose: The aim of this prospective study was to analyze dosimetric impact of modifying bladder filling on dosedistribution in organs at risk (OARs) when using contrast in the small bowel of patients under adjuvant therapy withhigh-dose-rate vaginal cuff brachytherapy (HDR-VCB) for endometrial cancer.Material and methods: This research included 19 patients who underwent laparoscopic surgery. They were treatedwith HDR-VCB and 2.5-3.5 cm diameter cylinders. Two successive computerized tomography (CT) scans were performed,with empty bladder and with bladder filled with 180 cc of saline solution. Bladder, rectum, sigmoid, and smallbowel were delineated as OARs. Oral barium contrast was used to clearly visualize small bowel loops. Prescriptiondose was 7 Gy. Dose-volume histograms were generated for each OAR, with full and empty bladder to compare dosesreceived.Results: Bladder distension had no dosimetric impact on the bladder, rectum, or sigmoid, unlike the small bowel.With full bladder, mean minimum dose at 2 cc (D2cc) was not significantly higher for full vs. empty bladder (5.56 vs.5.06 Gy, p = 0.07), whereas there was a significant reduction in the small bowel (1.68 vs. 2.70 Gy, p < 0.001). With fullbladder, the dose increased to 50% of the volume (D50%) of the bladder (2.11 vs. 1.28 Gy, p < 0.001), and decreased inthe small bowel (0.70 vs. 1.09 Gy, p < 0.001).Conclusions: The present study describes the dose received by organs at risk during HDR-VCB, making it possibleto define the dose received by small bowel loops, when visualized with oral barium contrast. In patients undergoinglaparoscopic surgery, a full bladder during HDR-VCB reduces the dose to the small bowel without a clinically relevantdose increase in the bladder, and no dose increase in other OARs.
PB TERMEDIA PUBLISHING HOUSE LTD
SN 1689-832X
YR 2021
FD 2021
LK http://hdl.handle.net/10498/26418
UL http://hdl.handle.net/10498/26418
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026