RT journal article
T1 Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection
A1 Márquez Coello, María de las Mercedes
A1 Ruiz Sánchez, Cristina
A1 Martín Aspas, Andrés
A1 Fernández-Gutiérrez del Álamo, Clotilde
A1 Illanes Álvarez, Francisco
A1 Cuesta Sancho, Sara
A1 Girón González, José Antonio
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
K1 HIV
K1 neutrophils
K1 BAFF
K1 APRIL
K1 bacterial translocation
K1 interleukins
K1 arginase-1
K1 PDL-1
AB ObjectiveEvaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients. MethodsHIV load, bacterial translocation and neutrophils' expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules were analyzed in different cohorts and time points: a control group of 25 healthy individuals and two groups of HIV-infected patients. Group 1 of patients included 35 untreated patients, studied at baseline and after antiretroviral therapy (ART). Group 2 was composed of 25 patients with undetectable viral load after a median of 101 months of ART prior to inclusion in the study. ResultsCompared with the control group, group 1 patients showed increased bacterial translocation and their PMN had a significantly higher expression of T and B-cell immunomodulatory molecules, both at baseline and after 12 months of ART. Group 2 patients showed reduced bacterial translocation levels when compared with group 1 patients after 12 months of treatment. PMN expression of B-cell modulators was similar between group 2 patients and healthy controls, although the expression of T-cell modulators remained increased. ConclusionIn HIV-infected patients, the expression of B-cell stimulatory and T-cell suppressive molecules by neutrophils was increased at baseline and after a limited time of therapy. After a prolonged period of ART, only PMNs expression of T-cell immunosuppressive molecules remained elevated.
PB FRONTIERS MEDIA SA
SN 1664-3224
YR 2021
FD 2021-12
LK http://hdl.handle.net/10498/26419
UL http://hdl.handle.net/10498/26419
LA eng
NO This work was supported by the Instituto de Salud Carlos III, Accion Estrategica en Salud 2014 (No PI14/01779), Spain. Cofinanced by FEDER (Fondo Europeo de Desarrollo Regional
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026