RT journal article
T1 Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity
A1 Cuevas, Belén
A1 Arroba Espinosa, Ana Isabel
A1 Reyes Jiménez, Carolina de los
A1 Gómez Jaramillo, María Laura
A1 González Montelongo, María del Carmen
A1 Zubía Mendoza, Eva
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 diterpenoids
K1 brown algae
K1 Rugulopteryx okamurae
K1 anti-inflammatory
K1 nitric oxide
K1 cytokine
K1 microglia
K1 macrophages
K1 invasive algae
AB Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids,whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, thechemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids:rugukadiol A (1), rugukamurals A–C (2–4), and ruguloptones A–F (6–10). The structures of thenew compounds were established by spectroscopic means. Compound 1 exhibits an unprecedentedditerpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2–10 belong to thesecospatane class of diterpenoids and differ by the oxygenated functions that they contain. In antiinflammatoryassays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited theproduction of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophagecells RAW264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2and the pro-inflammatory cytokine Il1b in both immune cell lines.
PB MDPI
SN 1660-3397
YR 2021
FD 2021-12
LK http://hdl.handle.net/10498/26422
UL http://hdl.handle.net/10498/26422
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026