RT journal article
T1 Current Understanding of the Physiopathology, Diagnosis and Therapeutic Approach to Alzheimer's Disease
A1 García Morales, Victoria
A1 González Acedo, Anabel
A1 Melguizo-Rodríguez, Lucía
A1 Pardo-Moreno, Teresa
A1 Costela-Ruiz, Víctor Javier
A1 Montiel-Troya, María
A1 Ramos-Rodríguez, Juan José
A2 BiomedicinaBiotecnología y Salud Pública
K1 Alzheimer’s disease
K1 senile plaques
K1 -amyloid protein
K1 diagnosis
K1 biomarker
K1 treatment
K1 acetylcholinesterase inhibitors
K1 immunotherapy
AB Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by cognitive decline and progressive memory loss. The aim of this review was to update the state of knowledge on the pathophysiological mechanisms, diagnostic methods and therapeutic approach to AD. Currently, the amyloid cascade hypothesis remains the leading theory in the pathophysiology of AD. This hypothesis states that amyloid-beta (A beta) deposition triggers a chemical cascade of events leading to the development of AD dementia. The antemortem diagnosis of AD is still based on clinical parameters. Diagnostic procedures in AD include fluid-based biomarkers such as those present in cerebrospinal fluid and plasma or diagnostic imaging methods. Currently, the therapeutic armory available focuses on symptom control and is based on four pillars: pharmacological treatment where acetylcholinesterase inhibitors stand out; pharmacological treatment under investigation which includes drugs focused on the control of A beta pathology and tau hyperphosphorylation; treatment focusing on risk factors such as diabetes; or nonpharmacological treatments aimed at preventing development of the disease or treating symptoms through occupational therapy or psychological help. AD remains a largely unknown disease. Further research is needed to identify new biomarkers and therapies that can prevent progression of the pathology.
PB MDPI
SN 2227-9059
YR 2021
FD 2021-12
LK http://hdl.handle.net/10498/26432
UL http://hdl.handle.net/10498/26432
LA eng
NO L.M.-R. and J.J.R.-R. are funded by P20-01293 from Junta de Andalucia, Spain. J.J.R.-R. is additionally funded by PECART-0096-2020 from Junta de Andalucia, Spain and PID2020-117544RB-100 from the Ministry of Science and Innovation, Spain.
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026