RT journal article
T1 Cortisol and Dexamethasone Mediate Glucocorticoid Actions in the Lesser Spotted Catshark (Scyliorhinus canicula)
A1 Cabrera-Busto, Juncal
A1 Mancera Romero, Juan Miguel
A1 Ruiz Jarabo de la Rocha, Ignacio
A2 Biología
K1 cortisol
K1 dexamethasone
K1 glucocorticoid receptors
K1 Scyliorhinus canicula
K1 sharks
AB Corticosteroids are hormones produced in vertebrates exerting gluco- and mineralocorticoidactions (GC and MC) mediated by specific receptors (GR and MR, respectively). In elasmobranchs,the major circulating corticosteroid is the 1 -hydroxycorticosterone (1 -OHB). This hormone actsas a MC, but to date its role as a GC has not been established. As there is no 1 -OHB standardavailable, here we employed a set of in vivo and ex vivo approaches to test GC actions of othercorticosteroids in the lesser spotted catshark (Scyliorhinus canicula). Dexamethasone (DEX, a syntheticcorticosteroid) slow-release implants decreased plasma 1 -OHB levels after 7 days, and modifiedcarbohydrates metabolism in liver and white muscle (energy stores and metabolic enzymes). Inaddition, ex vivo culture of liver and white muscle explants confirmed GC actions of corticosteroidsnot naturally present in sharks (cortisol and DEX) by increasing glucose secretion from these tissues.Dose–response curves induced by cortisol and DEX, altogether with the use of specific GR inhibitormifepristone, confirmed the involvement of GR mediating glucose secretion. This study highlightsthe influence of corticosteroids in the glucose balance of S. canicula, though the role of 1 -OHB as aGC hormone in sharks should be further confirmed.
PB MDPI
SN 2079-7737
YR 2022
FD 2022-01
LK http://hdl.handle.net/10498/26486
UL http://hdl.handle.net/10498/26486
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026