RT journal article
T1 Strategies for the synthesis of canonical, non-canonical and analogues of strigolactones, and evaluation of their parasitic weed germination activity
A1 García Zorrilla, Jesús
A1 Rial Cumbrera, Carlos
A1 Varela Montoya, Rosa María
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A2 Química Orgánica
K1 Natural product chemistry
K1 Organic synthesis
K1 Strigolactones
K1 Analogues
K1 GR24
K1 Parasitic weeds
AB Strigolactones (SLs) are natural products with promising applications as agrochemicals to prevent infestation with parasitic weeds due to their ability to trigger seed germination. However, their use is still limited because of the low yields in which they are isolated from natural sources. As such, numerous studies have led to strategies for obtaining them, and various structural analogues, by organic synthesis. These analogues have focused attention on the study of SLs, as some of them are easier to synthesize and possess enhanced properties, such as the level of bioactivity. This review provides an overview of the synthesis of SLs, subsequently focusing on the production of analogues with the canonical structure. The germinating activity of the compounds is also described herein, with positive effects on different species of the problematic genera Striga, Orobanche and Phelipanche having been found. The highly active analogue GR24 is currently the most widely studied in the literature, and relevant structural-activity relationships have been proposed as a result of the study of derivatives functionalized in different positions. Analogues based on other natural SLs such as strigol and orobanchol have also been developed, as have some novel canonical SLs derived from eudesmanolide or guaianolide sesquiterpene lactones. This review aims to provide useful information for the development of bioactive compounds applicable in new generation herbicides, in an attempt to employ similar compounds to those produced naturally in ecosystems that provoke effective herbicide effects at low concentrations.
PB SPRINGER
SN 1568-7767
YR 2022
FD 2022-01
LK http://hdl.handle.net/10498/26500
UL http://hdl.handle.net/10498/26500
LA eng
NO This work was supported by the ``Ministerio de Economi ' a, Industria y Competitividad'' (MINEICO), Spain, Project AGL2017-88-083-R.
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026