RT journal article
T1 Exercise and Childhood Cancer-A Historical Review
A1 Morales Rojas, JavierSalvador
A1 Valenzuela, Pedro L.
A1 Velázquez Díaz, Daniel
A1 Castillo-García, Adrián
A1 Jiménez Pavón, David
A1 Lucia, Alejandro
A1 Fiuza-Luces, Carmen
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 physical activity
K1 survival
K1 stem cell transplantation
K1 leukemia
K1 solid tumors
K1 exercise is medicine
AB Childhood cancer survivors are at risk of developing important adverse effects, but there is growing evidence that physical exercise could help in this regard. The present review summarizes the history of pediatric exercise oncology and the main milestones achieved along the way. Overall, physical exercise appears to be safe and beneficial even during the most aggressive phases of pediatric cancer treatment and can represent an effective coadjuvant therapy for attenuating cancer-related adverse effects. Childhood cancer survivors are at risk of developing important adverse effects, many of which persist for years after the end of treatment. The implementation of interventions aiming at attenuating tumor/treatment-associated adverse effects is therefore a major issue in pediatric oncology, and there is growing evidence that physical exercise could help in this regard. The present review aims to summarize the main milestones achieved in pediatric exercise oncology. For this purpose, we conducted a systematic review of relevant studies written in English in the electronic database PubMed (from inception to 14 August 2021). This review traces the field of pediatric exercise oncology throughout recent history based on three fundamental pillars: (i) exercise during childhood cancer treatment; (ii) exercise during/after hematopoietic stem cell transplantation; and (iii) exercise after childhood cancer treatment. Accumulating evidence--although still preliminary in many cases--supports the safety and potential benefits of regular exercise (with no major contraindications in general) in the childhood cancer continuum, even during the most aggressive phases of treatment. Exercise can indeed represent an effective coadjuvant therapy for attenuating cancer-related adverse effects.
PB MDPI
SN 2072-6694
YR 2022
FD 2022-01
LK http://hdl.handle.net/10498/26520
UL http://hdl.handle.net/10498/26520
LA eng
NO Research in pediatric/adolescent cancer by Alejandro Lucia and Carmen Fiuza-Luces is funded by: 'the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant #IIG_FULL_2021_007), the Spanish Ministry of Science and Innovation (Fondo de Investigaciones Sanitarias [FIS]) and Fondos FEDER (grant numbers PI18/00139 and PI20/00645); the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos III, post-doctoral contract Miguel Servet, #CP18/00034); and by a grant from the National Strength and Conditioning Association (NCSA) Foundation.
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026