RT journal article
T1 An Attempt to Optimize Supercritical CO2 Polyaniline-Polycaprolactone Foaming Processes to Produce Tissue Engineering Scaffolds
A1 Montes Herrera, Antonio
A1 Valor López, Diego
A1 Delgado, Laura
A1 Pereyra López, Clara María
A1 Martínez de la Ossa Fernández, Enrique José
A2 Ingeniería Química y Tecnología de Alimentos
K1 polycaprolactone
K1 polyaniline
K1 supercritical CO2 foaming
K1 scaffolds
K1 conjugated polymers
AB Conjugated polymers are biomaterials with high conductivity characteristics because of their molecular composition. However, they are too rigid and brittle for medical applications and therefore need to be combined with non-conductive polymers to overcome or lessen these drawbacks. This work has, consequently, focused on the development of three-dimensional scaffolds where conductive and non-conductive polymers have been produced by combining polycaprolactone (PCL) and polyaniline (PANI) by means of supercritical CO2 foaming techniques. To evaluate their therapeutic potential as implants, a series of experiments have been designed to determine the most influential variables in the production of the three-dimensional scaffolds, including temperature, pressure, polymer ratio and depressurization rate. Internal morphology, porosity, expansion factor, PANI loads, biodegradability, mechanical and electrical properties have been taken as the response variables. The results revealed a strong influence from all the input variables studied, as well as from their interactions. The best operating conditions tested were 70 degrees C, 100 bar, a ratio of 5:1 (PCL:PANI), a depressurization rate of 20 bar/min and a contact time of 1 h.
PB MDPI
SN 2073-4360
YR 2022
FD 2022-02
LK http://hdl.handle.net/10498/26535
UL http://hdl.handle.net/10498/26535
LA eng
NO This research was funded by Spanish Ministry of Economy, Industry and Competitiveness: PID2020-116229RB-I00.
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026