RT journal article T1 Effect of Blood Flow Restriction on Functional, Physiological and Structural Variables of Muscle in Patients with Chronic Pathologies: A Systematic Review A1 Reina-Ruiz, Álvaro Jesús A1 Galán Mercant, Alejandro A1 Molina Torres, Guadalupe A1 Merchán-Baeza, Jose Antonio A1 Romero-Galisteo, Rita Pilar A1 Gonzalez-Sanchez, Manuel A2 Enfermería y Fisioterapia K1 blood flow restriction K1 musculoskeletal disease K1 controlled tourniquet K1 chronic pathologies K1 occlusion resistance training AB The main objective of this systematic review of the current literature is to analyze the changes that blood flow restriction (BFR) causes in subjects with neuro-musculoskeletal and/or systemic pathologies focusing on the following variables: strength, physiological changes, structural changes and cardiocirculatory variables. The search was carried out in seven databases, including randomized clinical trials in which therapeutic exercise was combined with the blood flow restriction tool in populations with musculoskeletal pathologies. Outcome variables are strength, structural changes, physiological changes and cardiocirculatory variables. Twenty studies were included in the present study. Although there is a lot of heterogeneity between the interventions and evaluation instruments, we observed how the restriction of blood flow presents significant differences in the vast majority of the variables analyzed. In addition, we observed how BFR can become a supplement that provides benefits when performed with low intensity, similar to those obtained through high-intensity muscular efforts. The application of the BFR technique can provide benefits in the short and medium term to increase strength, muscle thickness and cardiovascular endurance, even improving the physiological level of the cardiovascular system. In addition, BFR combined with low-load exercises also achieves benefits comparable to high-intensity exercises without the application of BFR, benefiting patients who are unable to lift high loads. PB MDPI SN 1660-4601 YR 2022 FD 2022-02 LK http://hdl.handle.net/10498/26546 UL http://hdl.handle.net/10498/26546 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 21-sep-2026