RT journal article
T1 Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus
A1 Pardos-Blas, José R.
A1 Jiménez Tenorio, Manuel
A1 García Galindo, Juan Carlos
A1 Zardoya, Rafael
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
A2 Química Orgánica
K1 cone snails
K1 conotoxins
K1 venom duct transcriptomes
K1 venom duct proteomes
K1 Virroconus ebraeus
K1 Virroconus judaeus
K1 differential expression
K1 Cerm03
K1 SF-mi2
K1 insulin
AB The venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared. The most abundant and shared conotoxin precursor superfamilies in both species were M, O1, and O2. Additionally, three new putative conotoxin precursor superfamilies (Virro01-03) with cysteine pattern types VI/VII and XVI were identified. The most expressed conotoxin precursor superfamilies were SF-mi2 and M in V. ebraeus, and Cerm03 and M in V. judaeus. Up to 16 conotoxin precursor superfamilies and hormones were differentially expressed between both species, and clustered into two distinct sets, which could represent adaptations of each species to different diets. Finally, we predicted, with machine learning algorithms, the 3D structure model of selected venom proteins including the differentially expressed Cerm03 and SF-mi2, an insulin type 3, a Gastridium geographus GVIA-like conotoxin, and an ortholog to the Pionoconus magus omega-conotoxin MVIIA (Ziconotide).
PB MDPI
SN 1660-3397
YR 2022
FD 2022-02
LK http://hdl.handle.net/10498/26591
UL http://hdl.handle.net/10498/26591
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026