RT journal article
T1 Fetal cerebral three-dimensional power Doppler vascularization indices and their relationships with maternal glucose levels in pregnancies complicated with gestational diabetes
A1 Pérez-Martín, Sara M.
A1 Quintero Prado, Rocío
A1 Lara-Barea, Almudena
A1 López Tinoco, Cristina
A1 Torrejón Cardoso, Rafael
A1 Bugatto González, Fernando
A2 Materno-Infantil y Radiología
K1 Gestational diabetes
K1 obstetrics
K1 three dimensional power Doppler
K1 middle cerebral artery
K1 fetal cerebral vascularization
K1 flow index
AB Objectives We aimed to evaluate fetal cerebral circulation using three-dimensional power Doppler (3DPD) vascular indices and to study their relationships with maternal lipid and glycaemic profiles. Methods Case-control study in women with and without gestational diabetes mellitus (GDM) at 28-32 weeks in which feto-maternal Doppler study and 3DPD cerebral vascularization indices (FI, VI and VFI) were determined. Maternal lipid and glycaemic profiles were also analysed. Both groups were compared and the correlations of the 3DPD indices with studied variables were analysed. Results There were significant differences between groups in cerebral FI (p= 0.02), mean maternal Uterine artery PI (p= 0.009) and glucose levels (p= 0.001), being higher in the GDM group. Significant negative correlations were found in GDM group between VFI and MCA PI (p = 0.02) and between VI and MCA PI (p= 0.01). In the GDM group we found a negative significant correlation between FI, VI, VFI and maternal glucose (r= -0.52, p<0.001; r= -0.32, p=0.03 and r= -0.36, p= 0.01, respectively). Conclusions Fetal cerebral FI values were higher in GDM pregnancies. All 3DPD vascular indices showed an inverse correlation with maternal glucose levels. These findings support the view that GDM may also represent a fetal vascular disorder influencing fetal neurodevelopment.
PB SAGE PUBLICATIONS LTD
SN 1479-1641
YR 2022
FD 2022-01
LK http://hdl.handle.net/10498/26596
UL http://hdl.handle.net/10498/26596
LA eng
NO The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a grant from the Carlos III Health Institute (PI16/00370) to C. Lopez-Tinoco and F. Bugatto.
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026