RT journal article
T1 Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
A1 Giorgi-Pierfranceschi, Matteo
A1 Monreal, Manuel
A1 Di Micco, Pierpaolo
A1 Francisco, Iria
A1 Hernández-Blasco, Luis
A1 Madridano, Olga
A1 López Sáez, José Juan Bosco
A1 Hernando, Elena
A1 Meireles, Jose
A1 Dentali, Francesco
A1 RIETE Investigators
A2 Medicina
K1 venous thromboembolism
K1 mortality
K1 cigarette smoking
AB Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbolica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking patients) were included. After a median follow-up of 8.8 months, 7110 patients died (fatal PE 292 and fatal bleeding 281), 3243 presented VTE recurrence, and 1579 had major bleeding. At multivariate analysis, smoking behavior was associated with a higher hazard of death, (HR: 1.28; 95% CI: 1.19-1.40). The risk of VTE recurrence was marginally increased in smoking patients compared to non-smoking patients (1.14; 95% CI: 1.02-1.27). Major bleeding did not differ in smoking and non-smoking patients (1.15; 95% CI: 0.96-1.38). The presence of cancer did not appear to influence the association between smoking habits and death (HR: 1.34; 95% CI: 1.22-1.47 in cancer patients and HR: 1.23; 95% CI: 1.04, 1.45 in non-cancer patients, respectively) Conclusions: the risk of death after an acute episode of VTE appeared to be higher in smoking than in non-smoking patients and this risk is higher between patients presenting PE at the onset of symptoms.
PB MDPI
SN 1010-660X
YR 2022
FD 2022-02
LK http://hdl.handle.net/10498/26636
UL http://hdl.handle.net/10498/26636
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026