RT journal article
T1 IL-1 beta Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis
A1 Cano-Cano, Fátima
A1 Gómez Jaramillo, María Laura
A1 Ramos García, Pablo
A1 Arroba Espinosa, Ana Isabel
A1 Aguilar Diosdado, Manuel
A2 BiomedicinaBiotecnología y Salud Pública
K1 IL-1
K1 type 1 diabetes mellitus
K1 chronic inflammation
K1 systematic review
K1 meta-analysis
AB During Type 1 Diabetes Mellitus (T1DM) progression, there is chronic and low-grade inflammation that could be related to the evolution of the disease. We carried out a systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers such as interleukin-1 beta (IL-1 beta) is significantly different among patients with or without T1DM, in gender, management of the T1DM, detection in several biological fluids, study design, age range, and glycated hemoglobin. We searched PubMed, Embase, Web of Science, and Scopus databases, and 26 relevant studies (2186 with T1DM, 2047 controls) were included. We evaluated the studies' quality using the Newcastle-Ottawa scale. Meta-analyses were conducted, and heterogeneity and publication bias were examined. Compared with controls, IL-1 beta determined by immunoassays (pooled standardized mean difference (SMD): 2.45, 95% CI = 1.73 to 3.17; p < 0.001) was significantly elevated in T1DM. The compared IL-1 beta levels in patients < 18 years (SMD = 2.81, 95% CI = 1.88-3.74) was significantly elevated. The hemoglobin-glycated (Hbg) levels in patients < 18 years were compared (Hbg > 7: SMD = 5.43, 95% CI = 3.31-7.56; p = 0.001). Compared with the study design, IL-1 beta evaluated by ELISA (pooled SMD = 3.29, 95% CI = 2.27 to 4.30, p < 0.001) was significantly elevated in T1DM patients. IL-1 beta remained significantly higher in patients with a worse management of T1DM and in the early stage of T1DM. IL-1 beta levels determine the inflammatory environment during T1DM.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-03
LK http://hdl.handle.net/10498/26687
UL http://hdl.handle.net/10498/26687
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026