RT journal article
T1 Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites
A1 Coca Ruiz, Víctor
A1 Suárez Cáceres, Ivonne Rocío
A1 Aleu Casatejada, Josefina
A1 González Collado, Isidro
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 11,12,13-tri-nor-sesquiterpenes
K1 isolation
K1 biosynthesis
K1 biological activity
AB The compounds 11,12,13-tri-nor-sesquiterpenes are degraded sesquiterpenoids which have lost the C-3 unit of isopropyl or isopropenyl at C-7 of the sesquiterpene skeleton. The irregular C-backbone originates from the oxidative removal of a C-3 side chain from the C-15 sesquiterpene, which arises from farnesyl diphosphate (FDP). The C-12 -framework is generated, generally, in all families of sesquiterpenes by oxidative cleavage of the C-3 substituent, with the simultaneous introduction of a double bond. This article reviews the isolation, biosynthesis and biological activity of this special class of sesquiterpenes, the 11,12,13-tri-nor-sesquiterpenes.
PB MDPI
SN 2223-7747
YR 2022
FD 2022-03
LK http://hdl.handle.net/10498/26712
UL http://hdl.handle.net/10498/26712
LA eng
NO This research was supported by grant from MICIU (RTI2018-097356-B-C21, MCIU/AEI/FEDER, EU).
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026