RT journal article
T1 Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches
A1 Pinedo Rivilla, Cristina
A1 Aleu Casatejada, Josefina
A1 Durán Patrón, Rosa María
A2 Química Orgánica
K1 cryptic metabolite
K1 marine-derived microorganism
K1 OSMAC strategy
K1 chemical elicitor
K1 enzyme inhibitor
K1 epigenetic modifier
AB Marine microorganisms have proven to be a source of new natural products with a wide spectrum of biological activities relevant in different industrial sectors. The ever-increasing number of sequenced microbial genomes has highlighted a discrepancy between the number of gene clusters potentially encoding the production of natural products and the actual number of chemically characterized metabolites for a given microorganism. Homologous and heterologous expression of these biosynthetic genes, which are often silent under experimental laboratory culture conditions, may lead to the discovery of new cryptic natural products of medical and biotechnological interest. Several new genetic and cultivation-based strategies have been developed to meet this challenge. The OSMAC approach (one strain-many compounds), based on modification of growth conditions, has proven to be a powerful strategy for the discovery of new cryptic natural products. As a direct extension of this approach, the addition of chemical elicitors or epigenetic modifiers have also been used to activate silent genes. This review looks at the structures and biological activities of new cryptic metabolites from marine-derived microorganisms obtained using the OSMAC approach, the addition of chemical elicitors, and enzymatic inhibitors and epigenetic modifiers. It covers works published up to June 2021.
PB MDPI
SN 1660-3397
YR 2022
FD 2022-02
LK http://hdl.handle.net/10498/26860
UL http://hdl.handle.net/10498/26860
LA eng
NO This work was co-financed by the 2014-2020 ERDF Operational Programme and by the Department of Economy, Knowledge, Business and University of the Regional Government of Andalusia (Project reference: FEDER-UCA18-105749), and by The International Campus of Excellence in Marine Science (CEIMAR) within the framework of the scientific improvement actions contemplated in its Action Plan (Project reference: CEIJ-C06.1).
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026