RT journal article
T1 Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure
A1 Caravaca Perez, Pedro
A1 González-Juanatey, José R.
A1 Nuche, Jorge
A1 Matute-Blanco, Lucia
A1 Serrano, Isabel
A1 Martínez-Sellés, Manuel
A1 Vázquez García, Rafael
A1 Martínez Dolz, Luis
A1 Gómez-Bueno, Paloma
A1 Pascual-Figal, Domingo
A1 Crespo-Leiro, Marisa
A1 García-Osuna, Álvaro
A1 Ordoñez-Llanos, Jordi
A1 Cinca Cuscullola, Juan
A1 Guerra, José M.
A1 Delgado, Juan F.
A2 Medicina
K1 acute heart failure (AHF)
K1 galectin-3 (Gal-3)
K1 cardiorenal syndrome (CRS)
K1 renal function
K1 prognosis
AB IntroductionGalectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode. Materials and MethodsThis is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR >= 60 mL/min/1.73 m(2)) and renal dysfunction (eGFR <60 mL/min/1.73 m(2)). Cox regression analysis was performed to evaluate the association between Gal-3 and 12-month mortality. ResultsWe included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3-32.1). Gal-3 showed a negative correlation with eGFR (rho = -0.51; p < 0.001). Gal-3 concentrations were associated with higher mortality risk in the multivariate analysis after adjusting for eGFR and other prognostic variables [HR = 1.010 (95%-CI: 1.001-1.018); p = 0.038]. However, the prognostic value of Gal-3 was restricted to patients with renal dysfunction [HR = 1.010 (95%-CI: 1.001-1.019), p = 0.033] with optimal cutoff point of 31.5 ng/mL, with no prognostic value in the group with preserved renal function [HR = 0.990 (95%-CI: 0.964-1.017); p = 0.472]. ConclusionsGal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.
PB FRONTIERS MEDIA SA
SN 2297-055X
YR 2022
FD 2022-04
LK http://hdl.handle.net/10498/27072
UL http://hdl.handle.net/10498/27072
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026