RT journal article
T1 IBRORS-MCL study: a Spanish retrospective and observational study of relapsed/refractory mantle-cell lymphoma treated with ibrutinib in routine clinical practice
A1 Sancho, Juan-Manuel
A1 Marín‑Niebla, Ana
A1 Fernández, Silvia
A1 Capote Huelva, Francisco Javier
A1 Cañigral, Carolina
A1 Grande, Carlos
A1 Donato, Eva
A1 Zeberio, Izaskun
A1 Puerta, Jose-Manuel
A1 Rivas, Alfredo
A1 Pérez‑Ceballos, Elena
A1 Vale, Ana
A1 García‑Sancho, Alejandro Martín
A1 Salar, Antonio
A1 González‑Barca, Eva
A1 Teruel, Anabel
A1 Pastoriza, Carmen
A1 Conde‑Royo, Diego
A1 Sánchez‑García, Joaquín
A1 Barrenetxea, Cristina
A1 Arranz, Reyes
A1 Hernández‑Rivas, Jose-Angel
A1 Ramírez, María‑José
A1 Jiménez, Aroa
A1 Rubio‑Azpeitia, Eva
A2 Medicina
K1 Mantle-cell lymphoma
K1 Relapsed/refractory
K1 Ibrutinib
K1 Clinical practice
K1 Real-world evidence
AB This retrospective study evaluated 66 patients diagnosed with relapsed and/or refractory mantle cell lymphoma (R/R MCL)treated with ibrutinib in Spain in routine clinical practice. At diagnosis, patients had a median age of 64.5 years, 63.6% presentedwith intermediate/high sMIPI (simplified prognostic index for advanced-stage mantle cell lymphoma), 24.5% had theblastoid variant, and 55.6% had a Ki67 > 30%. Patients had received a median of 2 prior lines of therapy (range 1–2; min–max1–7). Overall response rate was 63.5%, with 38.1% of patients achieving complete response (CR). With a median duration ofibrutinib exposure of 10.7 months (range 5.2–19.6; min–max 0.3–36), the median progression-free survival (PFS) and overallsurvival (OS) were 20 months [95% confidence interval (CI) 8.8–31.1] and 32 months (95% CI 22.6–41.3), respectively, andwere not reached in patients achieving CR. No grade ≥ 3 cardiovascular toxicity or bleeding was reported. This study supportsthat treatment with ibrutinib leads to high response rates and favorable survival outcomes in patients with R/R MCL.
PB SPRINGER
SN 1865-3774
YR 2022
FD 2022-05
LK http://hdl.handle.net/10498/27140
UL http://hdl.handle.net/10498/27140
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026