RT journal article
T1 Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
A1 Alonso Piñero, José Ángel
A1 González Rovira, Almudena
A1 Sánchez Gomar, Ismael
A1 Durán Ruiz, María del Carmen
A2 BiomedicinaBiotecnología y Salud Pública
K1 atherosclerosis
K1 oxidative stress
K1 heme oxygenase-1
K1 Nrf2
AB Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties.
PB MDPI
SN 2076-3921
YR 2022
FD 2022-01
LK http://hdl.handle.net/10498/27142
UL http://hdl.handle.net/10498/27142
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026