RT journal article T1 Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response A1 Cuesta Sancho, Sara A1 Márquez Coello, María de las Mercedes A1 Illanes Álvarez, Francisco A1 Márquez Ruiz, Denisse A1 Arizcorreta Yarza, Ana A1 Galán Sánchez, Fátima A1 Montiel, Natalia A1 Rodríguez Iglesias, Manuel Antonio A1 Girón González, José Antonio A2 BiomedicinaBiotecnología y Salud Pública A2 Medicina K1 Hepatitis C virus K1 Sustained virological response K1 Direct antiviral agents K1 Human immunodeficiency virus K1 Cirrhosis decompensation K1 Hepatocarcinoma K1 Extrahepatic complications AB Loss of follow-up or reinfections hinder the expectations of hepatitis C eradicationdespite the existence of highly effective treatments. Moreover, the elimination ofthe infection does not imply the reversion of those chronic alterations derivedfrom the previous infection by hepatitis C virus (HCV). This review analyzes therisk factors associated with loss to follow-up in diagnosis or treatment, and thepossibility of reinfection. Likewise, it assesses the residual alterations induced bychronic HCV infection considering the liver alterations (inflammation, fibrosis,risk of decompensation, hepatocellular carcinoma, liver transplantation) and, onthe other hand, the comorbidities and extrahepatic manifestations (cryoglobulinemia,non-Hodgkin lymphoma, peripheral insulin resistance, and lipid, boneand cognitive alterations). Peculiarities present in subjects coinfected with humanimmunodeficiency virus are analyzed in each section. PB BAISHIDENG PUBLISHING GROUP INC SN 1948-5182 YR 2022 FD 2022-01 LK http://hdl.handle.net/10498/27161 UL http://hdl.handle.net/10498/27161 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 07-nov-2026