RT journal article
T1 Neuropsychiatric Symptoms in Clinically Defined Parkinson's Disease: An Updated Review of Literature
A1 Macias García, Paloma
A1 Rashid Abdu Rahim López, Raúl
A1 Cruz Gómez, Álvaro Javier
A1 Lozano Soto, Elena María
A1 Sanmartino, Florencia Soledad
A1 Espinosa Rosso, Raúl
A1 González Rosa, Javier Jesús
A2 Psicología
AB Background. Neuropsychiatric symptoms (NPS) are a common and potentially serious manifestation of Parkinson's disease (PD) but are frequently overlooked in favor of a focus on motor symptomatology. Here, we conducted a literature review of the prevalence and type of NPS experienced by PD patients with a clinically defined course of their illness. Methods. We identified reports of NPS in patients with PD and mean disease duration over 3 years. Three databases-PubMed, Scopus, and Dialnet-were searched for relevant literature published between 2010 and 2020. Predefined exclusion criteria were applied prior to a descriptive analysis of the literature base. Results. In all, 87 unique reports were identified and 30 met inclusion and exclusion criteria. These included 7142 patients with PD (male: 67.3%; mean age: 66.2 years; mean disease duration: 6.7 years). The most frequent NPS were mood disorders (apathy, depression, and anxiety), psychosis, and impulse control disorders (ICD). Treatment with dopamine agonists was identified as an important risk factor for ICD. Co-occurrence of NPS and cognitive dysfunction was also evidenced in a number of studies. Patients with more significant cognitive deficits and higher levels of NPS appeared to be of older age with a longer disease duration and to have more severe motor symptoms. Conclusions. NPS, most commonly mood disorders (apathy, depression, and anxiety), psychosis, and ICDs are frequent manifestations of PD. The results of this review reflect the need to develop unified validated assessment protocols for NPS in PD, as well as to improve their management in clinical practice.
PB HINDAWI LTD
SN 0953-4180
YR 2022
FD 2022-05
LK http://hdl.handle.net/10498/27170
UL http://hdl.handle.net/10498/27170
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026