RT journal article
T1 A New Perspective on Huntington's Disease: How a Neurological Disorder Influences the Peripheral Tissues
A1 Gómez Jaramillo, María Laura
A1 Cano-Cano, Fátima
A1 González Montelongo, María del Carmen
A1 Campos Caro, Antonio
A1 Aguilar Diosdado, Manuel
A1 Arroba Espinosa, Ana Isabel
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
K1 Huntington’s disease
K1 peripheral tissues
K1 animal models
K1 experimental approaches
AB Huntington’s disease (HD) is a neurodegenerative disorder caused by a toxic, aggregationproneexpansion of CAG repeats in the HTT gene with an age-dependent progression that leads tobehavioral, cognitive and motor symptoms. Principally affecting the frontal cortex and the striatum,mHTT disrupts many cellular functions. In fact, increasing evidence shows that peripheral tissuesare affected by neurodegenerative diseases. It establishes an active crosstalk between peripheraltissues and the brain in different neurodegenerative diseases. This review focuses on the currentknowledge of peripheral tissue effects in HD animal and cell experimental models and identifiesbiomarkers and mechanisms involved or affected in the progression of the disease as new therapeuticor early diagnostic options. The particular changes in serum/plasma, blood cells such as lymphocytes,immune blood cells, the pancreas, the heart, the retina, the liver, the kidney and pericytes as a partof the blood–brain barrier are described. It is important to note that several changes in differentmouse models of HD present differences between them and between the different ages analyzed. Theunderstanding of the impact of peripheral organ inflammation in HD may open new avenues for thedevelopment of novel therapeutic targets.
PB MDPI
SN 1422-0067
YR 2022
FD 2022-06
LK http://hdl.handle.net/10498/27304
UL http://hdl.handle.net/10498/27304
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026