RT journal article
T1 Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
A1 Estella García, Ángel
A1 Cantón, María Luisa
A1 Muñoz, Laura
A1 Rodriguez Higueras, Isabel
A1 Recuerda Núñez, María
A1 Tejero Aranguren, Julia
A1 Zaya, Benito
A1 Gómez, Carmen
A1 Amaya, Roario
A1 Hurtado Martinez, Ángela
A1 Odero Bernal, María del Valle
A1 De la Fuente, Carmen
A1 Alados Arboledas, Juan Carlos
A1 Garnacho-Montero, José
A2 Medicina
K1 SARS-CoV-2
K1 severe pneumonia
K1 acute respiratory distress syndrome
K1 vaccine
K1 ICU
K1 Delta variant SARS-CoV-2
AB Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised
PB MDPI
SN 2075-4426
YR 2021
FD 2021-11
LK http://hdl.handle.net/10498/27309
UL http://hdl.handle.net/10498/27309
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026