RT journal article
T1 Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications
A1 Machado,  Noelia Daiana
A1 Cejudo Bastante, Cristina
A1 Goñi, María L.
A1 Gañán, Nicolás A.
A1 Casas Cardoso, Lourdes
A1 Mantell Serrano, Casimiro
A2 Ingeniería Química y Tecnología de Alimentos
K1 olive leaves extract
K1 polylactic acid
K1 thermoplastic polyurethane
K1 supercritical impregnation
K1 antioxidant activity
AB The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO2 (scCO(2)), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable filaments of thermoplastic polyurethane (TPU) and polylactic acid (PLA) were employed for the supercritical impregnation of ethanolic olive leaves extract (OLE) for biomedical application. The extraction of OLE was performed using pressurized liquids. The effect of pressure (100-400 bar), temperature (35-55 degrees C), and the polymer type on the OLE impregnation and the swelling degree were studied including a morphological analysis and the measurement of the final antioxidant activity. All the studied variables as well as their interactions showed significant effects on the OLE loading. Higher temperatures favored the OLE loading while the pressure presented opposite effects at values higher than 250 bar. Thus, the highest OLE loadings were achieved at 250 bar and 55 degrees C for both polymers. However, TPU showed c.a. 4 times higher OLE loading and antioxidant activity in comparison with PLA at the optimal conditions. To the best of our knowledge, this is the first report using TPU for the supercritical impregnation of a natural extract with bioactivity.
PB MDPI
SN 2076-3921
YR 2022
FD 2022-06
LK http://hdl.handle.net/10498/27519
UL http://hdl.handle.net/10498/27519
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026