RT journal article T1 Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer's Disease A1 Ávila-Villanueva, Marina A1 Marcos Dolado, Alberto A1 Gómez Ramírez, Jaime D. A1 Fernández-Blázquez, Miguel A. A2 Psicología K1 structural changes K1 functional changes K1 early markers K1 reversion K1 cognitive impairment (CI) AB Cognitive neuropsychology seeks a potential alignment between structural andfunctional brain features to explain physiological or pathological processes, such asAlzheimer’s disease (AD). Several structural and functional brain changes occurringduring the disease, including cognitive impairment, are found at the end of the patient’slife, but we need to know more about what happens before its onset. In order to dothat, we need earlier biomarkers at preclinical stages, defined by those biomarkers,to prevent the cognitive impairment. In this minireview, we have tried to describe thestructural and functional changes found at different stages during AD, focusing on thosefeatures taking place before clinical diagnosis. PB FRONTIERS MEDIA SA SN 1664-1078 YR 2022 FD 2022-06 LK http://hdl.handle.net/10498/27537 UL http://hdl.handle.net/10498/27537 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 12-nov-2026